SymMap integrates traditional Chinese medicine (TCM) with modern medicine (MM) through both internal molecular mechanism and external symptom mapping, thus provides massive information on herbs/ingredients, targets, as well as the clinical symptoms and diseases they are used to treat for drug screening efforts.
Now, we update the SymMap database into version 2.0 to embrace the recent data update. First, we invited medical experts to manually extract and proofread newly recorded herbs, symptoms, syndromes and the relationships among them based on new Chinese Pharmacopoeia. Second, we obtained lots of high-quality relationships among herbs, ingredients and proteins and evidentiary literatures and texts that supports these relationships through the combination of information extraction and strict manual review by medical experts. Third, according to the data of mass spectrum experiments from Chinese Pharmacopoeia (2020 edition) and biomedical literatures, we further annotated the TCM ingredients into 4 categories, including QC ingredients, blood ingredients, metabolic ingredients, as well as other ingredients. Finally, for users’ convenience, the detailed relationships among symptoms and ingredients are shown as network figures. And a convenient function of GO/pathway enrichment for gene targets is presented in a user-defined way.
Wu Y#, Zhang F#, Yang K#, Fang S, Bu D, Li H, Sun L, Hu H, Gao K, Wang W, Zhou X*, Zhao Y*, Chen J*. SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping. Nucleic Acids Research 2018, 47(D1): D1110-D1117.